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Drug Interactions With the Rotavirus Vaccine

When immunosuppressants or immune globulins are taken with the rotavirus vaccine, drug interactions may occur. Children taking an immunosuppressant may not receive the full benefit of the rotavirus vaccine, since the immune system may not be fully capable of responding to the medication. Also, immune globulins may interfere with the rotavirus vaccine and decrease its effectiveness.

An Overview of Drug Interactions With the Rotavirus Vaccine

The rotavirus vaccine (Rotarix®, RotaTeq®) can potentially interact with a few medications. Some of the medicines that may lead to interactions with the rotavirus vaccine include:
 
  • Immune globulins
  • Immunosuppressants, such as:

 

 

 

    • Chemotherapy (as well as radiation treatment)
    • Corticosteroids, such as:

 

      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)

 

    • Cyclophosphamide (Cytoxan®)
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Etanercept (Enbrel®)
    • Methotrexate (Rheumatrex®)
    • Mycophenolate (CellCept®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®).

 


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(Drug Interactions With the Rotavirus Vaccine Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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