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Drug Interactions With the Rotavirus Vaccine

When immunosuppressants or immune globulins are taken with the rotavirus vaccine, drug interactions may occur. Children taking an immunosuppressant may not receive the full benefit of the rotavirus vaccine, since the immune system may not be fully capable of responding to the medication. Also, immune globulins may interfere with the rotavirus vaccine and decrease its effectiveness.

An Overview of Drug Interactions With the Rotavirus Vaccine

In March 2010, the United States Food and Drug Administration (FDA) recommended that Rotarix not be used, at least temporarily, since DNA from porcine circovirus type 1 (PCV1) has been found in the vaccine. This means that DNA from a virus found in pigs has been found in the vaccine. However, in May 2010, the FDA announced that it is safe to begin using Rotarix again, since PCV1 poses no known health risks to humans.
No similar problems have been found with RotaTeq.
The rotavirus vaccine (Rotarix, RotaTeq) can potentially interact with a few medications. Some of the medicines that may lead to interactions with the rotavirus vaccine include:
  • Immune globulins
  • Immunosuppressants, such as:



    • Chemotherapy (as well as radiation treatment)
    • Corticosteroids, such as:


      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)



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Rotavirus Vaccine Information

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